EFFERVESCENT TABLET FORMULATION ETHANOL EXTRACTS 70% KELAKAI ROOT (STENOCHLAENA PALUTRIS (BURM. F.) BEDD.) WITH VARIATION CONCENTRATION OF GAS GENERATING AGENT

Objective: The aim of this study is to determine the optimal formula effervescent tablets 70% ethanol extract Kelakai root (Stenochlaena palutris (Burm. f.) Bedd.) with variations concentration in gas generating agents and their effects on properties physical tablet.
 Methods: was extracted maceration using 70%, total phenolic-flavonoids contents were determined. Effervescent made for three formulas base varying agents. by wet granulation. Evaluation granules included flowability, tapped density, bulk angle repose. weight uniformity, thickness diameter, friability, pH, hardness, time, hedonic test.
 Results: had a phenolic content 625.35 μg GAE/mg extract, while flavonoid 735.24 QE/mg extract. have uniformity sizes ranging from 1.29 1.3 cm 0.49 0.5 cm, weights coefficient variation 1.04%-2.15%, fragility ranged 0.03%-0.29%, tablet hardness 8.33-9 kg, solubility 30-86 min. Statistical analysis showed that p-value is>0.05, which means there are no significant differences between concentrations citric acid tartaric influence characteristics tablets.
 Conclusion: Formula III best because it meets requirements hedonice test tablets.